Reactome | GSTs transfer GSH to NAPQI to form APAP-SG

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GSTs transfer GSH to NAPQI to form APAP-SG Show undefined attributes

catalystActivity	[CatalystActivity:10723800] glutathione transferase activity of GSTM1,P1,T1 dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10723802
displayName	GSTs transfer GSH to NAPQI to form APAP-SG
eventOf	[Pathway:R-XTR-9753281] Paracetamol ADME - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9753634] GGT dimers hydrolyse APAP-SG - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9753280] GSTs transfer GSH to NAPQI to form APAP-SG - Homo sapiens
input	[SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-9753466] NAPQI [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GSTs transfer GSH to NAPQI to form APAP-SG
output	[SimpleEntity:R-ALL-9753685] APAP-SG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-XTR-9753285] CYP2E1 monooxygenates APAP to NAPQI - Xenopus tropicalis [Reaction:R-XTR-174394] GSS:Mg2+ dimer synthesizes GSH - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9753280
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9753281] Paracetamol ADME
(precedingEvent)	[Reaction:R-XTR-9753634] GGT dimers hydrolyse APAP-SG
(inferredTo)	[Reaction:R-HSA-9753280] GSTs transfer GSH to NAPQI to form APAP-SG

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