Reactome | ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA

Schema > Reaction > Entries

ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10659850] CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10723731
displayName	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA
eventOf	[Pathway:R-XTR-9749641] Aspirin ADME - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9750001] GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9749971] ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-9750012] 2,5-DHBA [mitochondrial matrix] [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA 2,5-DHBA + Coenzyme A + ATP => 2,5-DHBA-CoA + AMP + pyrophosphate 2,5-DHBA and Coenzyme A react to form 2,5-DHBA-CoA thioester
output	[SimpleEntity:R-ALL-9749985] 2,5-DHB-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-159448] AMP [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9749971
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9749641] Aspirin ADME
(precedingEvent)	[Reaction:R-XTR-9750001] GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid
(inferredTo)	[Reaction:R-HSA-9749971] ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA

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