Reactome | phospho-rb1 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-188373] CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-188386] Association of Rb with Cyclin E:Cdk2 complexes - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652227
displayName	phospho-rb1 [nucleoplasm]
endCoordinate	928
hasModifiedResidue	[ModifiedResidue:10652225] O-phospho-L-serine at 230 (in Homo sapiens)
inDisease	false
inferredFrom	[DefinedSet:R-HSA-9687348] monophosphorylated RB1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9687336] p-S230-RB1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-rb1 p-S230-RB1 A0A6I8SAB1
producedByEvent	[Reaction:R-XTR-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Xenopus tropicalis
referenceEntity	[ReferenceGeneProduct:uniprot:A0A6I8SAB1] UniProt:A0A6I8SAB1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9687336
startCoordinate	2

(input)	[Reaction:R-XTR-188386] Association of Rb with Cyclin E:Cdk2 complexes
(hasComponent)	[Complex:R-XTR-188373] CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm]
(output)	[Reaction:R-XTR-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
(inferredTo)	[DefinedSet:R-HSA-9687348] monophosphorylated RB1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9687336] p-S230-RB1 [nucleoplasm]

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