Reactome | p-S54-PDE4B hydrolyses cAMP

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p-S54-PDE4B hydrolyses cAMP Show undefined attributes

catalystActivity	[CatalystActivity:10721930] 3',5'-cyclic-AMP phosphodiesterase activity of p-S54-PDE4B-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10721932
displayName	p-S54-PDE4B hydrolyses cAMP
eventOf	[Pathway:R-XTR-180024] DARPP-32 events - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9644869] p-S54-PDE4B hydrolyses cAMP - Homo sapiens
input	[SimpleEntity:R-ALL-30389] cAMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-S54-PDE4B hydrolyses cAMP cAMP hydrolysis by PDE4B
output	[SimpleEntity:R-ALL-76577] AMP [cytosol]
precedingEvent	[Reaction:R-XTR-111930] Adenylate cyclase produces cAMP - Xenopus tropicalis [Reaction:R-XTR-177284] PKA phosphorylates PDE4B - Xenopus tropicalis [Reaction:R-XTR-170676] Adenylate cyclase converts ATP into cyclic AMP - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9644869
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-180024] DARPP-32 events
(inferredTo)	[Reaction:R-HSA-9644869] p-S54-PDE4B hydrolyses cAMP

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