Reactome | JMJD6 dimer hydroxylates lysine residues of U2AF2

Schema > Reaction > Entries

JMJD6 dimer hydroxylates lysine residues of U2AF2 Show undefined attributes

catalystActivity	[CatalystActivity:10721617] peptidyl-lysine 5-dioxygenase activity of JMJD6 dimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10721619
displayName	JMJD6 dimer hydroxylates lysine residues of U2AF2
eventOf	[Pathway:R-XTR-9629569] Protein hydroxylation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5982] peptidyl-lysine hydroxylation
inferredFrom	[Reaction:R-HSA-9630022] JMJD6 dimer hydroxylates lysine residues of U2AF2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] 2 × [SimpleEntity:R-ALL-113685] O2 [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-71987] u2af2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	JMJD6 dimer hydroxylates lysine residues of U2AF2 2-oxoglutarate + L-lysyl-(protein) + O2 => (5S)-5-hydroxy-L-lysyl-(protein) + CO2 + succinate
output	2 × [SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] 2 × [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-9630011] u2af2 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9630022
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9629569] Protein hydroxylation
(inferredTo)	[Reaction:R-HSA-9630022] JMJD6 dimer hydroxylates lysine residues of U2AF2

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