Reactome | PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10713301] protein serine/threonine kinase activity of PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-XTR-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10713293
displayName	PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
hasComponent	[Complex:R-XTR-167712] AP-2 Complex [cytosol] [Complex:R-XTR-8856809] clathrin triskelion [cytosol] [DefinedSet:R-XTR-8854795-3] Homologues of AAK1 [cytosol] [CandidateSet:R-XTR-8863469] NECAPs [cytosol] [Complex:R-XTR-8862276] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-8868048] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] - Homo sapiens
maxDepth	6
name	PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8868048
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-XTR-8856813] AAK1 phosphorylates AP-2 mu subunit at T156
(physicalEntity)	[CatalystActivity:10713301] protein serine/threonine kinase activity of PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
(inferredTo)	[Complex:R-HSA-8868048] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]

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