Reactome | AP-2 Complex [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-XTR-8935902] Clathrin-coated vesicle [cytosol] - Xenopus tropicalis [Complex:R-XTR-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] - Xenopus tropicalis [Complex:R-XTR-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-9681616] AP2 binds chlorpromazine - Xenopus tropicalis [Reaction:R-XTR-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Xenopus tropicalis [Reaction:R-XTR-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10695624
displayName	AP-2 Complex [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-XTR-182143] AP2A1 [cytosol] [EntityWithAccessionedSequence:R-XTR-182166] ap2b1 [cytosol] [EntityWithAccessionedSequence:R-XTR-182227] AP2M1 [cytosol] [GenomeEncodedEntity:R-XTR-182197] Ghost homologue of AP2S1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-167712] AP-2 Complex [cytosol] - Homo sapiens
maxDepth	2
name	AP-2 Complex
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-167712
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-XTR-8935902] Clathrin-coated vesicle [cytosol] [Complex:R-XTR-8868048] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-XTR-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-XTR-9681612] AP2:chlorpromazine [cytosol] [Complex:R-XTR-5138434] clathrin:AP-2 [plasma membrane]
(input)	[Reaction:R-XTR-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-XTR-9681616] AP2 binds chlorpromazine
(inferredTo)	[Complex:R-HSA-167712] AP-2 Complex [cytosol]

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