Reactome | Insulin receptor signalling cascade

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Insulin receptor signalling cascade Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728634
displayName	Insulin receptor signalling cascade
eventOf	[Pathway:R-XTR-74752] Signaling by Insulin receptor - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-74742] Phosphorylation of SHC1 - Xenopus tropicalis [Reaction:R-XTR-109813] GRB2-1 binds SOS1 - Xenopus tropicalis [Pathway:R-XTR-74713] IRS activation - Xenopus tropicalis [Pathway:R-XTR-112399] IRS-mediated signalling - Xenopus tropicalis [Pathway:R-XTR-74749] Signal attenuation - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-74751] Insulin receptor signalling cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	Insulin receptor signalling cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-74751
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-74752] Signaling by Insulin receptor
(inferredTo)	[Pathway:R-HSA-74751] Insulin receptor signalling cascade

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