Reactome | IRS-mediated signalling

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728644
displayName	IRS-mediated signalling
eventOf	[Pathway:R-XTR-2428928] IRS-related events triggered by IGF1R - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-74737] p-Y-IRS1,p-Y-IRS2 bind PI3K - Xenopus tropicalis [Pathway:R-XTR-109704] PI3K Cascade - Xenopus tropicalis [Pathway:R-XTR-112412] SOS-mediated signalling - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-112399] IRS-mediated signalling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	5
name	IRS-mediated signalling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-112399
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-2428928] IRS-related events triggered by IGF1R [Pathway:R-XTR-74751] Insulin receptor signalling cascade
(inferredTo)	[Pathway:R-HSA-112399] IRS-mediated signalling