Reactome | Creatine metabolism

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Creatine metabolism Show undefined attributes

compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:17927] mitochondrial intermembrane space [Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728540
displayName	Creatine metabolism
eventOf	[Pathway:R-XTR-71291] Metabolism of amino acids and derivatives - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:10792] creatine metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-XTR-71275] arginine + glycine => ornithine + guanidoacetate - Xenopus tropicalis [Reaction:R-XTR-71286] guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine - Xenopus tropicalis [Reaction:R-XTR-200318] creatine + ATP => phosphocreatine + ADP [CKB,CKM] - Xenopus tropicalis [Reaction:R-XTR-200326] creatine + ATP => phosphocreatine + ADP [CK octamer] - Xenopus tropicalis [Reaction:R-XTR-200396] Creatine transport across the plasma membrane - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-71288] Creatine metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Creatine metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-71288
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-71291] Metabolism of amino acids and derivatives
(inferredTo)	[Pathway:R-HSA-71288] Creatine metabolism