Reactome | VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

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VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) Show undefined attributes

catalystActivity	[CatalystActivity:10710250] vitamin-K-epoxide reductase (warfarin-sensitive) activity of VKORC1L1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10710252
displayName	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)
eventOf	[Pathway:R-XTR-6806664] Metabolism of vitamin K - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6806647] VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - Homo sapiens
input	2 × [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-6806366] MK4 epoxide [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) MK4 epoxide => MK4
output	[SimpleEntity:R-ALL-6806362] MK4 [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6806647
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-6806664] Metabolism of vitamin K
(inferredTo)	[Reaction:R-HSA-6806647] VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

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