Reactome | MAPK6/MAPK4 signaling

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MAPK6/MAPK4 signaling Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729816
displayName	MAPK6/MAPK4 signaling
eventOf	[Pathway:R-XTR-5683057] MAPK family signaling cascades - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-XTR-389788] Activation of PAKs by RAC1 and CDC42 - Xenopus tropicalis [Reaction:R-XTR-5627775] Autophosphorylation of PAK1,2,3 - Xenopus tropicalis [Reaction:R-XTR-5687086] PAK1,2,3 phosphorylates MAPK6,4 - Xenopus tropicalis [BlackBoxEvent:R-XTR-5687107] MAPK4,6 translocate to nucleus - Xenopus tropicalis [BlackBoxEvent:R-XTR-5687109] MAPK4,6 translocate to the cytoplasm - Xenopus tropicalis [BlackBoxEvent:R-XTR-5687112] MAPK6 is degraded by the 26S proteasome - Xenopus tropicalis [Reaction:R-XTR-5692755] CDK1 phosphorylates MAPK6 - Xenopus tropicalis [Reaction:R-XTR-5692749] CDC14A,B bind MAPK6 - Xenopus tropicalis [Reaction:R-XTR-5692754] CDC14A,B dephosphorylate p-3S,T MAPK6 - Xenopus tropicalis [Reaction:R-XTR-5687090] p-S MAPK6 phosphorylates NCOA3 - Xenopus tropicalis [Reaction:R-XTR-5687097] p-S857 NCOA3 binds ETV4 - Xenopus tropicalis [BlackBoxEvent:R-XTR-5687126] p-S215 FOXO3 translocates to the nucleus - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MAPK6/MAPK4 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5687128
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5683057] MAPK family signaling cascades
(inferredTo)	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling

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