Reactome | Negative regulation of MAPK pathway

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Negative regulation of MAPK pathway Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730878
displayName	Negative regulation of MAPK pathway
eventOf	[Pathway:R-XTR-5673001] RAF/MAP kinase cascade - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-5674140] PAQR3 binds inactive RAFs - Xenopus tropicalis [Pathway:R-XTR-5674499] Negative feedback regulation of MAPK pathway - Xenopus tropicalis [Reaction:R-XTR-5675417] PEBP1 binds activated RAF1 - Xenopus tropicalis [Reaction:R-XTR-5675433] PP5 dephosphorylates RAF1 S338 - Xenopus tropicalis [Reaction:R-XTR-5675431] PP2A dephosphorylates RAF1 - Xenopus tropicalis [Reaction:R-XTR-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Xenopus tropicalis [Reaction:R-XTR-5675373] Nuclear DUSPs dephosphorylate MAPKs - Xenopus tropicalis [Reaction:R-XTR-5674018] BRAP binds RAS:GTP - Xenopus tropicalis [Reaction:R-XTR-5674022] BRAP autoubiquitinates - Xenopus tropicalis [Reaction:R-XTR-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Xenopus tropicalis [Reaction:R-XTR-8867658] PTPN3 dephosphorylates MAPK12 - Xenopus tropicalis [Reaction:R-XTR-8868118] MAPK12 phosphorylates PTPN3 - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Negative regulation of MAPK pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5675221
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway

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