Reactome | GLI3 is partially degraded by the proteasome to yield the GLI3 repressor

Schema > BlackBoxEvent > Entries

GLI3 is partially degraded by the proteasome to yield the GLI3 repressor Show undefined attributes

catalystActivity	[CatalystActivity:10652009] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10698627
displayName	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
eventOf	[Pathway:R-XTR-5610785] GLI3 is processed to GLI3R by the proteasome - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-XTR-5610752] GLI3R translocates to the nucleus - Xenopus tropicalis
inferredFrom	[BlackBoxEvent:R-HSA-5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor - Homo sapiens
input	[Complex:R-XTR-5610526] 4xub-p13S-Gli3:SUFU [ciliary base]
isInDisease	false
isInferred	true
maxDepth	1
name	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
output	[EntityWithAccessionedSequence:R-XTR-5610369] gli3 [cytosol] [EntityWithAccessionedSequence:R-XTR-445455] sufu [cytosol]
precedingEvent	[Reaction:R-XTR-5610746] SCF(beta-TrCP) ubiquitinates p-GLI3 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5610754
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5610785] GLI3 is processed to GLI3R by the proteasome
(precedingEvent)	[BlackBoxEvent:R-XTR-5610752] GLI3R translocates to the nucleus
(inferredTo)	[BlackBoxEvent:R-HSA-5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor

Cite Us!