Reactome | h4c3 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-2245190] Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-2245190] Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-5423117] PHF8 demethylates MeK21-histone H4 - Xenopus tropicalis [Reaction:R-XTR-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10689571
displayName	h4c3 [nucleoplasm]
endCoordinate	103
hasModifiedResidue	[ModifiedResidue:10689569] N6-methyl-L-lysine at 21 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-5423110] MeK21-HIST1H4 [nucleoplasm] - Homo sapiens
maxDepth	1
name	h4c3 MeK21-HIST1H4 B5DDY3
producedByEvent	[Reaction:R-XTR-5423038] SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) - Xenopus tropicalis
referenceEntity	[ReferenceGeneProduct:uniprot:B5DDY3] UniProt:B5DDY3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5423110
startCoordinate	2

(input)	[Reaction:R-XTR-5423117] PHF8 demethylates MeK21-histone H4 [Reaction:R-XTR-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
(output)	[Reaction:R-XTR-5423038] SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)
(hasComponent)	[Complex:R-XTR-2245190] Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-5423110] MeK21-HIST1H4 [nucleoplasm]

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