Reactome | APEX1 [nucleoplasm]

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APEX1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-110334] APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110356] Displacement of MPG glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110350] Displacement of TDG glycosylase by APEX1 at the AP site - Xenopus tropicalis [Reaction:R-XTR-110349] Displacement of UNG glycosylase by APEX1 at the AP site - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10657453
displayName	APEX1 [nucleoplasm]
endCoordinate	318
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-50119] APEX1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	APEX1 Q6P2X0
producedByEvent	[Reaction:R-XTR-110375] Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break - Xenopus tropicalis [Reaction:R-XTR-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Xenopus tropicalis
referenceEntity	[ReferenceGeneProduct:uniprot:Q6P2X0] UniProt:Q6P2X0
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-50119
startCoordinate	2

Referrals

(output)	[Reaction:R-XTR-110375] Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break [Reaction:R-XTR-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
(activeUnit)	[CatalystActivity:10657478] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
(hasComponent)	[Complex:R-XTR-110334] APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] [Complex:R-XTR-5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Complex:R-XTR-5649859] APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] [Complex:R-XTR-110332] APEX1:AP-dsDNA [nucleoplasm]
(input)	[Reaction:R-XTR-110350] Displacement of TDG glycosylase by APEX1 at the AP site [Reaction:R-XTR-110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site [Reaction:R-XTR-110349] Displacement of UNG glycosylase by APEX1 at the AP site [Reaction:R-XTR-110356] Displacement of MPG glycosylase by APEX1 at the AP site [Reaction:R-XTR-110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Reaction:R-XTR-110355] Displacement of MUTYH glycosylase by APEX1 at the AP site [Reaction:R-XTR-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site [Reaction:R-XTR-110353] Displacement of MBD4 glycosylase by APEX1 at the AP site
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-50119] APEX1 [nucleoplasm]

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