Reactome | AUF1 (hnRNP D0) binds and destabilizes mRNA

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AUF1 (hnRNP D0) binds and destabilizes mRNA Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730068
displayName	AUF1 (hnRNP D0) binds and destabilizes mRNA
eventOf	[Pathway:R-XTR-450531] Regulation of mRNA stability by proteins that bind AU-rich elements - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:171831] regulation of mRNA stability
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-450434] AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA - Xenopus tropicalis [BlackBoxEvent:R-XTR-450580] AUF1 (hnRNP D0) is ubiquitinylated - Xenopus tropicalis [BlackBoxEvent:R-XTR-450466] AUF1:mRNA complex is degraded - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	AUF1 (hnRNP D0) binds and destabilizes mRNA
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-450408
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-450531] Regulation of mRNA stability by proteins that bind AU-rich elements
(inferredTo)	[Pathway:R-HSA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA

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