Reactome | CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1

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CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10694233
displayName	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1
eventOf	[Pathway:R-XTR-2559582] Senescence-Associated Secretory Phenotype (SASP) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 - Homo sapiens
input	[Complex:R-XTR-187952] CCNA:p-T160-CDK2 [nucleoplasm] [Complex:R-XTR-174250] Cdh1:phospho-APC/C complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1
output	[Complex:R-XTR-188374] Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm]
precedingEvent	[Reaction:R-XTR-187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 - Xenopus tropicalis [Reaction:R-XTR-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Xenopus tropicalis
regulatedBy	[NegativeRegulation:10694231] Negative regulation by 'Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3788708
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2559582] Senescence-Associated Secretory Phenotype (SASP)
(precedingEvent)	[Reaction:R-XTR-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2
(inferredTo)	[Reaction:R-HSA-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1

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