Reactome | ABCG1-mediated transport of intracellular cholesterol to the cell surface

Schema > Reaction > Entries

ABCG1-mediated transport of intracellular cholesterol to the cell surface Show undefined attributes

catalystActivity	[CatalystActivity:10668022] cholesterol transfer activity of ABCG1 dimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:13946] transport vesicle membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10668024
displayName	ABCG1-mediated transport of intracellular cholesterol to the cell surface
eventOf	[Pathway:R-XTR-8964058] HDL remodeling - Xenopus tropicalis [Pathway:R-XTR-1369062] ABC transporters in lipid homeostasis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-266299] Spherical HDL binds membrane-associated free cholesterol and phospholipids - Xenopus tropicalis [Reaction:R-XTR-266089] Discoidal HDL binds membrane-associated free cholesterol - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-266082] ABCG1-mediated transport of intracellular cholesterol to the cell surface - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-216762] CHOL [transport vesicle membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCG1-mediated transport of intracellular cholesterol to the cell surface
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-171095] CHOL [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-266082
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8964058] HDL remodeling [Pathway:R-XTR-1369062] ABC transporters in lipid homeostasis
(precedingEvent)	[Reaction:R-XTR-266299] Spherical HDL binds membrane-associated free cholesterol and phospholipids [Reaction:R-XTR-266089] Discoidal HDL binds membrane-associated free cholesterol
(inferredTo)	[Reaction:R-HSA-266082] ABCG1-mediated transport of intracellular cholesterol to the cell surface

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