Reactome | PPM1A protein phosphatase binds phosphorylated SMAD2/3

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PPM1A protein phosphatase binds phosphorylated SMAD2/3 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10689715
displayName	PPM1A protein phosphatase binds phosphorylated SMAD2/3
eventOf	[Pathway:R-XTR-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-209055] PPM1A dephosphorylates nuclear SMAD2/3 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Homo sapiens
input	[Complex:R-XTR-206827] p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-205813] ppm1a [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PPM1A protein phosphatase binds phosphorylated SMAD2/3
output	[Complex:R-XTR-2187392] p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-XTR-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2187388
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)	[Reaction:R-XTR-209055] PPM1A dephosphorylates nuclear SMAD2/3
(inferredTo)	[Reaction:R-HSA-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3

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