Reactome | The SMAD2/3:SMAD4 complex transfers to the nucleus

Schema > BlackBoxEvent > Entries

The SMAD2/3:SMAD4 complex transfers to the nucleus Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10661706
displayName	The SMAD2/3:SMAD4 complex transfers to the nucleus
eventOf	[Pathway:R-XTR-1181150] Signaling by NODAL - Xenopus tropicalis [Pathway:R-XTR-1502540] Signaling by Activin - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements - Xenopus tropicalis [Reaction:R-XTR-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Xenopus tropicalis [Reaction:R-XTR-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Xenopus tropicalis [Reaction:R-XTR-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Xenopus tropicalis [Reaction:R-XTR-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer - Xenopus tropicalis [Reaction:R-XTR-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 - Xenopus tropicalis [Reaction:R-XTR-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 - Xenopus tropicalis [Reaction:R-XTR-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 - Xenopus tropicalis [Reaction:R-XTR-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Xenopus tropicalis
inferredFrom	[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
input	[Complex:R-XTR-206866] p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	The SMAD2/3:SMAD4 complex transfers to the nucleus
output	[Complex:R-XTR-206827] p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm]
precedingEvent	[Reaction:R-XTR-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Xenopus tropicalis
regulatedBy	[NegativeRegulation:10661707] Negative regulation by 'p-T,Y MAPK dimers [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-173488
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1502540] Signaling by Activin [Pathway:R-XTR-1181150] Signaling by NODAL [Pathway:R-XTR-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
(precedingEvent)	[Reaction:R-XTR-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements [Reaction:R-XTR-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer [Reaction:R-XTR-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 [Reaction:R-XTR-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer [Reaction:R-XTR-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer [Reaction:R-XTR-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 [Reaction:R-XTR-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 [Reaction:R-XTR-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 [Reaction:R-XTR-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
(inferredTo)	[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus

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