Reactome | Arachidonate is oxidised to 15S-HpETE by ALOX15/15B

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Arachidonate is oxidised to 15S-HpETE by ALOX15/15B Show undefined attributes

catalystActivity	[CatalystActivity:10689133] arachidonate 15-lipoxygenase activity of ALOX15/15B [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10689135
displayName	Arachidonate is oxidised to 15S-HpETE by ALOX15/15B
eventOf	[Pathway:R-XTR-2142770] Synthesis of 15-eicosatetraenoic acid derivatives - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-2161791] 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 - Xenopus tropicalis [Reaction:R-XTR-2161917] ALOX5 oxidises 15S-HpETE to LXA4/B4 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Arachidonate is oxidised to 15S-HpETE by ALOX15/15B (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
output	[SimpleEntity:R-ALL-2142718] 15S-HpETE [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2162002
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2142770] Synthesis of 15-eicosatetraenoic acid derivatives
(precedingEvent)	[Reaction:R-XTR-2161791] 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 [Reaction:R-XTR-2161917] ALOX5 oxidises 15S-HpETE to LXA4/B4
(inferredTo)	[Reaction:R-HSA-2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B

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