Reactome | HDAC1 [nucleoplasm]

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HDAC1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-9022428] HDAC1 homodimer [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-9022428] HDAC1 homodimer [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-9858619] HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-9825719] HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-1227670] Recruitment of HDAC1 by p130 (RBL2) - Xenopus tropicalis [Reaction:R-XTR-9858647] HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter - Xenopus tropicalis [Reaction:R-XTR-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer - Xenopus tropicalis [Reaction:R-XTR-1227671] Recruitment of HDAC1 by p107 (RBL1) - Xenopus tropicalis [Reaction:R-XTR-9825754] HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10680400
displayName	HDAC1 [nucleoplasm]
endCoordinate	482
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-205021] HDAC1 [nucleoplasm] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-XTR-9938420] HDAC1,HDAC2 [nucleoplasm] - Xenopus tropicalis
name	HDAC1 Q5BL48
producedByEvent	[Reaction:R-XTR-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Xenopus tropicalis [Reaction:R-XTR-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Xenopus tropicalis
referenceEntity	[ReferenceGeneProduct:uniprot:Q5BL48] UniProt:Q5BL48
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-205021
startCoordinate	1

Referrals

(input)	[Reaction:R-XTR-9825754] HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter [Reaction:R-XTR-9858647] HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter [Reaction:R-XTR-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer [Reaction:R-XTR-1227671] Recruitment of HDAC1 by p107 (RBL1) [Reaction:R-XTR-1227670] Recruitment of HDAC1 by p130 (RBL2)
(hasComponent)	[Complex:R-XTR-9825719] HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] [Complex:R-XTR-9858619] HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] [Complex:R-XTR-8935726] RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] [Complex:R-XTR-9022428] HDAC1 homodimer [nucleoplasm] [Complex:R-XTR-3299553] TLE1:HDAC1 [nucleoplasm] [Complex:R-XTR-3772506] TLE:HDAC1 [nucleoplasm] [Complex:R-XTR-2186606] p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] [Complex:R-XTR-1227668] HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] [Complex:R-XTR-1227666] HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] [Complex:R-XTR-9009060] CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] [Complex:R-XTR-4657004] HDAC1:HDAC2 [nucleoplasm]
(hasMember)	[DefinedSet:R-XTR-9938420] HDAC1,HDAC2 [nucleoplasm] [DefinedSet:R-XTR-205005] Histone deacetylase [nucleoplasm]
(output)	[Reaction:R-XTR-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF [Reaction:R-XTR-9009065] FOXA1 and GATA3 bind to CCND1 promoter
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-205021] HDAC1 [nucleoplasm]

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