Reactome | Degradation multiubiquitinated Cyclin A

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Degradation multiubiquitinated Cyclin A Show undefined attributes

catalystActivity	[CatalystActivity:10652009] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10661995
displayName	Degradation multiubiquitinated Cyclin A
eventOf	[Pathway:R-XTR-174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 - Xenopus tropicalis
goBiologicalProcess	[GO_BiologicalProcess:160432] proteasome-mediated ubiquitin-dependent protein catabolic process
inferredFrom	[BlackBoxEvent:R-HSA-174255] Degradation multiubiquitinated Cyclin A - Homo sapiens
input	[Complex:R-XTR-174222] multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Degradation multiubiquitinated Cyclin A
output	[Complex:R-XTR-141410] MCC:APC/C complex [cytosol] [EntityWithAccessionedSequence:R-XTR-157415] phospho-p-T161-CDK1 [cytosol] 4 × [DefinedSet:R-XTR-113595] Ub [cytosol]
precedingEvent	[Reaction:R-XTR-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-174255
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A
(precedingEvent)	[Reaction:R-XTR-174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
(inferredTo)	[BlackBoxEvent:R-HSA-174255] Degradation multiubiquitinated Cyclin A