Reactome | benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

Schema > Reaction > Entries

benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate Show undefined attributes

catalystActivity	[CatalystActivity:10494384] CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10494386
displayName	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate
eventOf	[Pathway:R-XTR-177135] Conjugation of benzoate with glycine - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-159443] benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-159446] BENZA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
isInDisease	false
isInferred	true
name	benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate Benzoate and Coenzyme A react to form benzoyl-CoA thioester
output	[SimpleEntity:R-ALL-159448] AMP [mitochondrial matrix] [SimpleEntity:R-ALL-159447] BEZ-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-159443
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-177135] Conjugation of benzoate with glycine
(precedingEvent)	[Reaction:R-XTR-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A
(inferredTo)	[Reaction:R-HSA-159443] benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

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