Reactome | Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

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Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10682111
displayName	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
eventOf	[Pathway:R-XTR-1963642] PI3K events in ERBB2 signaling - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Xenopus tropicalis [Reaction:R-XTR-2316434] PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Homo sapiens
input	[Complex:R-XTR-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] [Complex:R-XTR-1806218] PIK3CA:PIK3R1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
output	[Complex:R-XTR-1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1306965
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1963642] PI3K events in ERBB2 signaling
(precedingEvent)	[Reaction:R-XTR-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-XTR-2316434] PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

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