Reactome | EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10682107] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10682106
displayName	EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
hasComponent	[Complex:R-XTR-1306962] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] [EntityWithAccessionedSequence:R-XTR-74787] pik3ca [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens
maxDepth	5
memberOf	[DefinedSet:R-XTR-2316432] Activator:PI3K [plasma membrane] - Xenopus tropicalis
name	EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K
producedByEvent	[Reaction:R-XTR-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1306961
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(physicalEntity)	[CatalystActivity:10682107] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
(output)	[Reaction:R-XTR-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
(hasMember)	[DefinedSet:R-XTR-2316432] Activator:PI3K [plasma membrane]
(inferredTo)	[Complex:R-HSA-1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]

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