Reactome | ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin

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ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin Show undefined attributes

catalystActivity	[CatalystActivity:10680941] protein serine/threonine kinase activity of Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10680943
displayName	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin
eventOf	[Pathway:R-XTR-1502540] Signaling by Activin - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin - Homo sapiens
input	[Complex:R-XTR-1549493] Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] 12 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin
output	[Complex:R-XTR-1549500] Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] 12 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-XTR-1181153] Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1181149
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1502540] Signaling by Activin
(precedingEvent)	[Reaction:R-XTR-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor
(inferredTo)	[Reaction:R-HSA-1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin

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