Reactome | CDH1 is proteolytically cleaved in Golgi

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CDH1 is proteolytically cleaved in Golgi Show undefined attributes

catalystActivity	[CatalystActivity:10550433] serine-type endopeptidase activity of FURIN, PCSK7,(PCSK6) [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10550435
displayName	CDH1 is proteolytically cleaved in Golgi
eventOf	[Pathway:R-SSC-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-9816278] CDH1 translocates to the plasma membrane - Sus scrofa [Reaction:R-SSC-9935209] CDH1 binds to PIP5K1C - Sus scrofa
inferredFrom	[Reaction:R-HSA-9816275] CDH1 is proteolytically cleaved in Golgi - Homo sapiens
input	2 × [SimpleEntity:R-ALL-2022884] H2O [Golgi lumen] [DefinedSet:R-SSC-9934365] Man,Man9GlucNAc2,p-3S-CDH1(23-882):CTNNB1,JUP [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CDH1 is proteolytically cleaved in Golgi
output	2 × [EntityWithAccessionedSequence:R-SSC-9933717] CDH1(23-154) [Golgi lumen] [DefinedSet:R-SSC-9934371] Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP [Golgi membrane]
precedingEvent	[BlackBoxEvent:R-SSC-9816273] CDH1 translocates from ER to Golgi - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9816275
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
(precedingEvent)	[BlackBoxEvent:R-SSC-9816278] CDH1 translocates to the plasma membrane [Reaction:R-SSC-9935209] CDH1 binds to PIP5K1C
(inferredTo)	[Reaction:R-HSA-9816275] CDH1 is proteolytically cleaved in Golgi