Reactome | CDH1 is proteolytically cleaved in Golgi

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CDH1 is proteolytically cleaved in Golgi Show undefined attributes

authored	[InstanceEdit:9816274] Orlic-Milacic, Marija, 2022-09-02
catalystActivity	[CatalystActivity:9933719] serine-type endopeptidase activity of FURIN, PCSK7,(PCSK6) [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:9816274] Orlic-Milacic, Marija, 2022-09-02
dbId	9816275
displayName	CDH1 is proteolytically cleaved in Golgi
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-9935209] CDH1 binds to PIP5K1C - Homo sapiens [Reaction:R-HSA-9934330] CDH1:CTNNB1,JUP complex binds to ANK3 - Homo sapiens [BlackBoxEvent:R-HSA-9816278] CDH1 translocates to the plasma membrane - Homo sapiens
input	2 × [SimpleEntity:R-ALL-2022884] H2O [Golgi lumen] [DefinedSet:R-HSA-9934365] Man,Man9GlucNAc2,p-3S-CDH1(23-882):CTNNB1,JUP [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9768713] Proprotein cleavage of E-cadherin by furin in baculovirus over-expression system: potential role of other convertases in mammalian cells [LiteratureReference:9768742] Multiple post-translational modifications regulate E-cadherin transport during apoptosis [LiteratureReference:9933825] PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation [LiteratureReference:9816226] Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CDH1 is proteolytically cleaved in Golgi
orthologousEvent	[Reaction:R-GGA-9816275] CDH1 is proteolytically cleaved in Golgi - Gallus gallus [Reaction:R-XTR-9816275] CDH1 is proteolytically cleaved in Golgi - Xenopus tropicalis [Reaction:R-DRE-9816275] CDH1 is proteolytically cleaved in Golgi - Danio rerio [Reaction:R-SSC-9816275] CDH1 is proteolytically cleaved in Golgi - Sus scrofa [Reaction:R-BTA-9816275] CDH1 is proteolytically cleaved in Golgi - Bos taurus [Reaction:R-CFA-9816275] CDH1 is proteolytically cleaved in Golgi - Canis familiaris [Reaction:R-RNO-9816275] CDH1 is proteolytically cleaved in Golgi - Rattus norvegicus [Reaction:R-MMU-9816275] CDH1 is proteolytically cleaved in Golgi - Mus musculus
output	2 × [EntityWithAccessionedSequence:R-HSA-9933717] CDH1(23-154) [Golgi lumen] [DefinedSet:R-HSA-9934371] Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP [Golgi membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9816273] CDH1 translocates from ER to Golgi - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9816275
summation	[Summation:9933711] Correct proteolytic cleavage of the proprotein of CDH1 (E...

Referrals

(hasEvent)	[Pathway:R-HSA-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
(precedingEvent)	[Reaction:R-HSA-9935209] CDH1 binds to PIP5K1C [Reaction:R-HSA-9934330] CDH1:CTNNB1,JUP complex binds to ANK3 [BlackBoxEvent:R-HSA-9816278] CDH1 translocates to the plasma membrane

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