Reactome | XDH oxidises 6MP to 6TU

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XDH oxidises 6MP to 6TU Show undefined attributes

catalystActivity	[CatalystActivity:10451477] xanthine oxidase activity of XDH dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10549028
displayName	XDH oxidises 6MP to 6TU
eventOf	[Pathway:R-SSC-9748787] Azathioprine ADME - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8768] xenobiotic catabolic process
inferredFrom	[Reaction:R-HSA-9748991] XDH oxidises 6MP to 6TU - Homo sapiens
input	[ChemicalDrug:R-ALL-9748998] 6MP [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	XDH oxidises 6MP to 6TU 6MP--XDH-->6TU
output	[SimpleEntity:R-ALL-9748978] 6TU [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-SSC-9748996] GST dimers cleave AZA to 6MP - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9748991
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9748787] Azathioprine ADME
(inferredTo)	[Reaction:R-HSA-9748991] XDH oxidises 6MP to 6TU

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