Reactome | Active FLT3 binds to SH2B3

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10547740
displayName	Active FLT3 binds to SH2B3
eventOf	[Pathway:R-SSC-9706369] Negative regulation of FLT3 - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9706315] Active FLT3 binds to SH2B3 - Homo sapiens
input	[Complex:R-SSC-9604751] Active FLT3 [plasma membrane] [EntityWithAccessionedSequence:R-SSC-997241] SH2B3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active FLT3 binds to SH2B3
output	[Complex:R-SSC-9706266] active FLT3:SH2B3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-SSC-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9706315
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-9706369] Negative regulation of FLT3
(inferredTo)	[Reaction:R-HSA-9706315] Active FLT3 binds to SH2B3

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