Reactome | FLT3LG dimer:FLT3 dimer autophosphorylates

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FLT3LG dimer:FLT3 dimer autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10545054] protein tyrosine kinase activity of FLT3LG dimer:FLT3 dimer [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10545060
displayName	FLT3LG dimer:FLT3 dimer autophosphorylates
eventOf	[Pathway:R-SSC-9607240] FLT3 Signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9699578] Active FLT3 phosphorylates CDKN1B - Sus scrofa [Reaction:R-SSC-9706315] Active FLT3 binds to SH2B3 - Sus scrofa [Reaction:R-SSC-9706298] Active FLT3 binds to CSK - Sus scrofa [Reaction:R-SSC-9706330] Active FLT3 binds to SOCS6 - Sus scrofa [Reaction:R-SSC-9706328] Active FLT3 binds to SOCS2 - Sus scrofa [Reaction:R-SSC-9706287] Active FLT3 binds to ABL2 - Sus scrofa [Reaction:R-SSC-9706319] Active FLT3 binds to SLA - Sus scrofa [Reaction:R-SSC-9706293] Active FLT3 binds to CBL - Sus scrofa [Reaction:R-SSC-9706304] Active FLT3 binds to GRAP2 - Sus scrofa [Reaction:R-SSC-9706312] Active FLT3 binds to LCK - Sus scrofa [Reaction:R-SSC-9706336] Active FLT3 binds to SYK - Sus scrofa [Reaction:R-SSC-9706308] Active FLT3 binds to GRB10 - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-8854716] FLT3LG dimer:FLT3 dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FLT3LG dimer:FLT3 dimer autophosphorylates
output	[Complex:R-SSC-9604751] Active FLT3 [plasma membrane] 12 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-SSC-8854736] FLT3LG dimer:FLT3 binds FLT3 - Sus scrofa
regulatedBy	[NegativeRegulation:10545061] Negative regulation by 'FLT3:FLT3-binding type II TKIs [plasma membrane]' [NegativeRegulation:10545062] Negative regulation by 'FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-9604767
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9607240] FLT3 Signaling
(precedingEvent)	[Reaction:R-SSC-9699578] Active FLT3 phosphorylates CDKN1B [Reaction:R-SSC-9706315] Active FLT3 binds to SH2B3 [Reaction:R-SSC-9706298] Active FLT3 binds to CSK [Reaction:R-SSC-9706330] Active FLT3 binds to SOCS6 [Reaction:R-SSC-9706328] Active FLT3 binds to SOCS2 [Reaction:R-SSC-9706287] Active FLT3 binds to ABL2 [Reaction:R-SSC-9706319] Active FLT3 binds to SLA [Reaction:R-SSC-9706293] Active FLT3 binds to CBL [Reaction:R-SSC-9706304] Active FLT3 binds to GRAP2 [Reaction:R-SSC-9706312] Active FLT3 binds to LCK [Reaction:R-SSC-9706336] Active FLT3 binds to SYK [Reaction:R-SSC-9706308] Active FLT3 binds to GRB10
(inferredTo)	[BlackBoxEvent:R-HSA-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates

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