Reactome | Interleukin-23 signaling

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Interleukin-23 signaling Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557423
displayName	Interleukin-23 signaling
eventOf	[Pathway:R-SSC-447115] Interleukin-12 family signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2266300] interleukin-23-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-8950183] IL12B binds IL23A - Sus scrofa [BlackBoxEvent:R-SSC-8950741] IL12B:IL23A translocates from ER lumen to extracellular space - Sus scrofa [BlackBoxEvent:R-SSC-447130] Interleukin-23 binds interleukin-23 receptor - Sus scrofa [BlackBoxEvent:R-SSC-8952749] STAT4 binds p-Y-IL23R in IL23:IL23 receptor - Sus scrofa [BlackBoxEvent:R-SSC-8950269] STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor - Sus scrofa [BlackBoxEvent:R-SSC-8952823] p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor - Sus scrofa [Reaction:R-SSC-8950780] p-Y705-STAT3 binds p-Y693-STAT4 - Sus scrofa [BlackBoxEvent:R-SSC-8950724] p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus - Sus scrofa
inferredFrom	[Pathway:R-HSA-9020933] Interleukin-23 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-23 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-9020933
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-447115] Interleukin-12 family signaling
(inferredTo)	[Pathway:R-HSA-9020933] Interleukin-23 signaling

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