Reactome | Ub [nucleoplasm]

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Ub [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-SSC-5655177] MonoUb:K15,K24-KIAA0101 [nucleoplasm] - Sus scrofa [Complex:R-SSC-5655177] MonoUb:K15,K24-KIAA0101 [nucleoplasm] - Sus scrofa [Complex:R-SSC-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] - Sus scrofa [Complex:R-SSC-6781851] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-6785361] Monoubiquitination of FANCD2:FANCI - Sus scrofa [Reaction:R-SSC-6785361] Monoubiquitination of FANCD2:FANCI - Sus scrofa [Reaction:R-SSC-6785361] Monoubiquitination of FANCD2:FANCI - Sus scrofa [Reaction:R-SSC-6785361] Monoubiquitination of FANCD2:FANCI - Sus scrofa [Reaction:R-SSC-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Sus scrofa [Reaction:R-SSC-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Sus scrofa [Reaction:R-SSC-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Sus scrofa [Reaction:R-SSC-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Sus scrofa [Reaction:R-SSC-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Sus scrofa [Reaction:R-SSC-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Sus scrofa [Reaction:R-SSC-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Sus scrofa [Reaction:R-SSC-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Sus scrofa [Reaction:R-SSC-3322429] XIAP monoubiquinates TLE - Sus scrofa [Reaction:R-SSC-6804942] MDM2 homodimers auto-ubiquitinate - Sus scrofa [Reaction:R-SSC-6804942] MDM2 homodimers auto-ubiquitinate - Sus scrofa [BlackBoxEvent:R-SSC-5655193] KIAA0101 double monoubiquitination - Sus scrofa [BlackBoxEvent:R-SSC-5655193] KIAA0101 double monoubiquitination - Sus scrofa [Reaction:R-SSC-5655170] RCHY1 monoubiquitinates POLH - Sus scrofa [Reaction:R-SSC-5655170] RCHY1 monoubiquitinates POLH - Sus scrofa [Reaction:R-SSC-5655170] RCHY1 monoubiquitinates POLH - Sus scrofa [Reaction:R-SSC-5655170] RCHY1 monoubiquitinates POLH - Sus scrofa [Reaction:R-SSC-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Sus scrofa [Reaction:R-SSC-8952419] SMURFs ubiquitinate RUNX3 - Sus scrofa [Reaction:R-SSC-8952419] SMURFs ubiquitinate RUNX3 - Sus scrofa [Reaction:R-SSC-8952419] SMURFs ubiquitinate RUNX3 - Sus scrofa [Reaction:R-SSC-8952382] MDM2 polyubiquitinates RUNX3 - Sus scrofa [Reaction:R-SSC-8952382] MDM2 polyubiquitinates RUNX3 - Sus scrofa [Reaction:R-SSC-8952382] MDM2 polyubiquitinates RUNX3 - Sus scrofa [Reaction:R-SSC-8952382] MDM2 polyubiquitinates RUNX3 - Sus scrofa [Reaction:R-SSC-8952382] MDM2 polyubiquitinates RUNX3 - Sus scrofa [Reaction:R-SSC-8952382] MDM2 polyubiquitinates RUNX3 - Sus scrofa [Reaction:R-SSC-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Sus scrofa [Reaction:R-SSC-6804253] MDM2 ubiquitinates JMY - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Sus scrofa [Reaction:R-SSC-2179276] SMURF2 monoubiquitinates SMAD3 - Sus scrofa [Reaction:R-SSC-2179276] SMURF2 monoubiquitinates SMAD3 - Sus scrofa [Reaction:R-SSC-2179276] SMURF2 monoubiquitinates SMAD3 - Sus scrofa [Reaction:R-SSC-2179276] SMURF2 monoubiquitinates SMAD3 - Sus scrofa [Reaction:R-SSC-2179276] SMURF2 monoubiquitinates SMAD3 - Sus scrofa [Reaction:R-SSC-2179276] SMURF2 monoubiquitinates SMAD3 - Sus scrofa [Reaction:R-SSC-870449] TRIM33 monoubiquitinates SMAD4 - Sus scrofa [Reaction:R-SSC-870449] TRIM33 monoubiquitinates SMAD4 - Sus scrofa [Reaction:R-SSC-870449] TRIM33 monoubiquitinates SMAD4 - Sus scrofa [Reaction:R-SSC-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2) - Sus scrofa [Reaction:R-SSC-187575] Ubiquitination of phospho-p27/p21 - Sus scrofa [Reaction:R-SSC-187575] Ubiquitination of phospho-p27/p21 - Sus scrofa [Reaction:R-SSC-187575] Ubiquitination of phospho-p27/p21 - Sus scrofa [Reaction:R-SSC-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Sus scrofa [Reaction:R-SSC-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Sus scrofa [Reaction:R-SSC-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Sus scrofa [Reaction:R-SSC-174057] Multiubiquitination of APC/C-associated Cdh1 - Sus scrofa [Reaction:R-SSC-174057] Multiubiquitination of APC/C-associated Cdh1 - Sus scrofa [Reaction:R-SSC-174057] Multiubiquitination of APC/C-associated Cdh1 - Sus scrofa [BlackBoxEvent:R-SSC-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Sus scrofa [BlackBoxEvent:R-SSC-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Sus scrofa [BlackBoxEvent:R-SSC-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Sus scrofa [Reaction:R-SSC-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - Sus scrofa [Reaction:R-SSC-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - Sus scrofa [Reaction:R-SSC-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - Sus scrofa [Reaction:R-SSC-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Sus scrofa [Reaction:R-SSC-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Sus scrofa [Reaction:R-SSC-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Sus scrofa [Reaction:R-SSC-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 - Sus scrofa [Reaction:R-SSC-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 - Sus scrofa [Reaction:R-SSC-6804441] RNF34 or RFFL ubiquitinates phosphorylated TP53 - Sus scrofa [Reaction:R-SSC-6798373] MDM2 ubiquitinates DYRK2 - Sus scrofa [Reaction:R-SSC-9708517] FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) - Sus scrofa [Reaction:R-SSC-9708517] FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) - Sus scrofa [Reaction:R-SSC-9708517] FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) - Sus scrofa [Reaction:R-SSC-6782943] UV-DDB ubiquitinates XPC - Sus scrofa [Reaction:R-SSC-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Sus scrofa [Reaction:R-SSC-8852128] UBA1 adenylates ubiquitin in the nucleoplasm - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10447149
displayName	Ub [nucleoplasm]
hasMember	[EntityWithAccessionedSequence:R-SSC-939849] RPS27A [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-939844] UBA52 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-939847] UBC [nucleoplasm] - Sus scrofa
inDisease	false
inferredFrom	[DefinedSet:R-HSA-68524] Ub [nucleoplasm] - Homo sapiens
maxDepth	2
name	Ub Ubiquitin UBIQ_HUMAN
producedByEvent	[Reaction:R-SSC-5655466] USP1:WDR48 deubiquitinates monoUb:K164-PCNA - Sus scrofa [Reaction:R-SSC-6786171] FANCD2 deubiquitination by USP1:WDR48 - Sus scrofa [Reaction:R-SSC-6786171] FANCD2 deubiquitination by USP1:WDR48 - Sus scrofa [Reaction:R-SSC-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Sus scrofa [BlackBoxEvent:R-SSC-188191] APC/C:Cdh1-mediated degradation of Skp2 - Sus scrofa [BlackBoxEvent:R-SSC-188191] APC/C:Cdh1-mediated degradation of Skp2 - Sus scrofa [BlackBoxEvent:R-SSC-188191] APC/C:Cdh1-mediated degradation of Skp2 - Sus scrofa [BlackBoxEvent:R-SSC-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Sus scrofa [BlackBoxEvent:R-SSC-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Sus scrofa [BlackBoxEvent:R-SSC-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Sus scrofa [BlackBoxEvent:R-SSC-68825] Ubiquitinated geminin is degraded by the proteasome - Sus scrofa [BlackBoxEvent:R-SSC-68825] Ubiquitinated geminin is degraded by the proteasome - Sus scrofa [BlackBoxEvent:R-SSC-68825] Ubiquitinated geminin is degraded by the proteasome - Sus scrofa [BlackBoxEvent:R-SSC-8939801] 26S proteasome degrades PolyUb-RUNX2 - Sus scrofa [BlackBoxEvent:R-SSC-8939801] 26S proteasome degrades PolyUb-RUNX2 - Sus scrofa [BlackBoxEvent:R-SSC-8939801] 26S proteasome degrades PolyUb-RUNX2 - Sus scrofa [Reaction:R-SSC-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Sus scrofa [Reaction:R-SSC-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Sus scrofa [Reaction:R-SSC-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Sus scrofa [Reaction:R-SSC-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Sus scrofa [Reaction:R-SSC-3215295] USP7 deubiquitinates MDM2 - Sus scrofa [Reaction:R-SSC-3215295] USP7 deubiquitinates MDM2 - Sus scrofa [Reaction:R-SSC-5690157] USP16,USP21 deubiquitinate Histone H2A - Sus scrofa [Reaction:R-SSC-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B - Sus scrofa [Reaction:R-SSC-5691381] MYSM1 deubiquitinates Histone H2A - Sus scrofa [Reaction:R-SSC-5690790] Histone H2A is dubiquitinated by the PR-DUB complex - Sus scrofa [Reaction:R-SSC-5653770] USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA - Sus scrofa [BlackBoxEvent:R-SSC-174058] Degradation of multiubiquitinated Cdh1 - Sus scrofa [BlackBoxEvent:R-SSC-174058] Degradation of multiubiquitinated Cdh1 - Sus scrofa [BlackBoxEvent:R-SSC-174058] Degradation of multiubiquitinated Cdh1 - Sus scrofa [Reaction:R-SSC-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Sus scrofa [Reaction:R-SSC-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Sus scrofa [Reaction:R-SSC-5696465] USP45 deubiquitinates ERCC1 - Sus scrofa [BlackBoxEvent:R-SSC-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Sus scrofa [BlackBoxEvent:R-SSC-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Sus scrofa [BlackBoxEvent:R-SSC-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Sus scrofa
schemaClass	DefinedSet
species	[Species:49633] Sus scrofa
stId	R-SSC-68524

Referrals

(hasComponent)	[Complex:R-SSC-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] [Complex:R-SSC-8852095] Ub-Cys632-UBA1 [nucleoplasm] [Complex:R-SSC-8942129] Ub:UBE2A,B [nucleoplasm] [Complex:R-SSC-8943019] Ub:UBE2N [nucleoplasm] [Complex:R-SSC-5655177] MonoUb:K15,K24-KIAA0101 [nucleoplasm] [Complex:R-SSC-5655156] MonoUb:K682,K686,K694,K709-POLH [nucleoplasm] [Complex:R-SSC-6785366] MonoUb:K91,K182-UBE2T [nucleoplasm] [Complex:R-SSC-420751] MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] [Complex:R-SSC-420750] MonoUb:K523,p-4S-FANCI [nucleoplasm] [Complex:R-SSC-6781849] Ub:ERCC6 [nucleoplasm] [Complex:R-SSC-5651984] MonoUb:K164-PCNA [nucleoplasm] [Complex:R-SSC-2186733] Ub-SKI/Ub-SKIL [nucleoplasm] [Complex:R-SSC-2186778] Ub-SMAD7 [nucleoplasm] [Complex:R-SSC-187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] [Complex:R-SSC-1363324] Ub-p-T401,S672,1035-RBL2 [nucleoplasm] [Complex:R-SSC-174068] multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] [Complex:R-SSC-2176504] Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] [Complex:R-SSC-1234123] UBE2D1,2,3:Ubiquitin [nucleoplasm] [Complex:R-SSC-1234100] ub-hydroxyPro-HIF-alpha [nucleoplasm] [Complex:R-SSC-3788734] Ub-EHMT1 [nucleoplasm] [Complex:R-SSC-3788727] Ub-EHMT2 [nucleoplasm] [Complex:R-SSC-6782951] Ub:XPC [nucleoplasm] [Complex:R-SSC-6790462] Ub,SUMO:XPC [nucleoplasm] [Complex:R-SSC-5696466] Ub:ERCC1 [nucleoplasm] [Complex:R-SSC-6781851] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm]
(input)	[Reaction:R-SSC-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus [Reaction:R-SSC-8852128] UBA1 adenylates ubiquitin in the nucleoplasm [BlackBoxEvent:R-SSC-5655193] KIAA0101 double monoubiquitination [Reaction:R-SSC-5655170] RCHY1 monoubiquitinates POLH [Reaction:R-SSC-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA [Reaction:R-SSC-8952419] SMURFs ubiquitinate RUNX3 [Reaction:R-SSC-8952382] MDM2 polyubiquitinates RUNX3 [Reaction:R-SSC-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 [Reaction:R-SSC-6804253] MDM2 ubiquitinates JMY [Reaction:R-SSC-6785361] Monoubiquitination of FANCD2:FANCI [Reaction:R-SSC-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II [Reaction:R-SSC-5682858] RNF8 and RNF168 ubiquitinate H2AFX [Reaction:R-SSC-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B [Reaction:R-SSC-2179276] SMURF2 monoubiquitinates SMAD3 [Reaction:R-SSC-870449] TRIM33 monoubiquitinates SMAD4 [Reaction:R-SSC-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2) [Reaction:R-SSC-187575] Ubiquitination of phospho-p27/p21 [Reaction:R-SSC-9686969] APC/C:Cdh1 polyubiquitinates SKP2 [Reaction:R-SSC-174057] Multiubiquitination of APC/C-associated Cdh1 [BlackBoxEvent:R-SSC-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 [Reaction:R-SSC-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin [Reaction:R-SSC-3322429] XIAP monoubiquinates TLE [Reaction:R-SSC-8939706] SCF(SKP2) polyubiquitinates RUNX2 [Reaction:R-SSC-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 [Reaction:R-SSC-6804942] MDM2 homodimers auto-ubiquitinate [Reaction:R-SSC-6804441] RNF34 or RFFL ubiquitinates phosphorylated TP53 [Reaction:R-SSC-6798373] MDM2 ubiquitinates DYRK2 [Reaction:R-SSC-9708517] FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) [Reaction:R-SSC-6782943] UV-DDB ubiquitinates XPC
(output)	[Reaction:R-SSC-5690157] USP16,USP21 deubiquitinate Histone H2A [Reaction:R-SSC-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B [Reaction:R-SSC-5691381] MYSM1 deubiquitinates Histone H2A [Reaction:R-SSC-5690790] Histone H2A is dubiquitinated by the PR-DUB complex [Reaction:R-SSC-5655466] USP1:WDR48 deubiquitinates monoUb:K164-PCNA [Reaction:R-SSC-5653770] USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA [Reaction:R-SSC-6786171] FANCD2 deubiquitination by USP1:WDR48 [Reaction:R-SSC-6782069] UVSSA:USP7 deubiquitinates ERCC6 [BlackBoxEvent:R-SSC-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome [BlackBoxEvent:R-SSC-174058] Degradation of multiubiquitinated Cdh1 [BlackBoxEvent:R-SSC-188191] APC/C:Cdh1-mediated degradation of Skp2 [BlackBoxEvent:R-SSC-69600] Proteolytic degradation of ubiquitinated-Cdc25A [BlackBoxEvent:R-SSC-68825] Ubiquitinated geminin is degraded by the proteasome [Reaction:R-SSC-6807118] USP7 deubiquitinates monoubiquitinated PTEN [BlackBoxEvent:R-SSC-8939801] 26S proteasome degrades PolyUb-RUNX2 [Reaction:R-SSC-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 [Reaction:R-SSC-3215295] USP7 deubiquitinates MDM2 [Reaction:R-SSC-5696465] USP45 deubiquitinates ERCC1
(inferredTo)	[DefinedSet:R-HSA-68524] Ub [nucleoplasm]

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