Reactome | NOX4, NOX5 reduce O2 to O2.-

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NOX4, NOX5 reduce O2 to O2.- Show undefined attributes

catalystActivity	[CatalystActivity:10530498] superoxide-generating NAD(P)H oxidase activity of NOX4, NOX5 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10530500
displayName	NOX4, NOX5 reduce O2 to O2.-
eventOf	[Pathway:R-SSC-3299685] Detoxification of Reactive Oxygen Species - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6807557] NOX4, NOX5 reduce O2 to O2.- - Homo sapiens
input	[SimpleEntity:R-ALL-29364] NADPH [cytosol] 2 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NOX4, NOX5 reduce O2 to O2.-
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-1222424] O2.- [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-6807557
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-3299685] Detoxification of Reactive Oxygen Species
(inferredTo)	[Reaction:R-HSA-6807557] NOX4, NOX5 reduce O2 to O2.-

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