Reactome | JAK1,TYK2 phosphorylate JAK1,TYK2

Schema > BlackBoxEvent > Entries

JAK1,TYK2 phosphorylate JAK1,TYK2 Show undefined attributes

catalystActivity	[CatalystActivity:10524300] protein tyrosine kinase activity of IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10524302
displayName	JAK1,TYK2 phosphorylate JAK1,TYK2
eventOf	[Pathway:R-SSC-6783783] Interleukin-10 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-6784319] JAK1,TYK2 phosphorylate JAK1,TYK2 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-449832] IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK1,TYK2 phosphorylate JAK1,TYK2
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-6784339] IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane]
precedingEvent	[Reaction:R-SSC-449811] IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 - Sus scrofa
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-6784319
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6783783] Interleukin-10 signaling
(precedingEvent)	[BlackBoxEvent:R-SSC-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
(inferredTo)	[BlackBoxEvent:R-HSA-6784319] JAK1,TYK2 phosphorylate JAK1,TYK2

Cite Us!