Reactome | Interleukin-10 signaling

Schema > Pathway > Entries

Interleukin-10 signaling Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557445
displayName	Interleukin-10 signaling
eventOf	[Pathway:R-SSC-449147] Signaling by Interleukins - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8651] cytokine-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-449855] IL10 dimerizes - Sus scrofa [Reaction:R-SSC-449803] IL10 dimer binds IL10RA:JAK1 - Sus scrofa [Reaction:R-SSC-449811] IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 - Sus scrofa [BlackBoxEvent:R-SSC-6784319] JAK1,TYK2 phosphorylate JAK1,TYK2 - Sus scrofa [BlackBoxEvent:R-SSC-6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA - Sus scrofa [Reaction:R-SSC-6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 - Sus scrofa [Reaction:R-SSC-6784006] STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 - Sus scrofa [Reaction:R-SSC-6784791] p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 - Sus scrofa [BlackBoxEvent:R-SSC-6784765] p-Y705-STAT3 dimerizes - Sus scrofa [BlackBoxEvent:R-SSC-6784763] p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm - Sus scrofa
inferredFrom	[Pathway:R-HSA-6783783] Interleukin-10 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-10 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-6783783
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-449147] Signaling by Interleukins
(hasEncapsulatedEvent)	[Pathway:R-SSC-201556] Signaling by ALK
(inferredTo)	[Pathway:R-HSA-6783783] Interleukin-10 signaling

© 2026 Reactome

Cite Us!