Reactome | PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser

Schema > Reaction > Entries

PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser Show undefined attributes

catalystActivity	[CatalystActivity:10522516] glycine hydroxymethyltransferase activity of PXLP-K280-SHMT2 tetramer [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10522518
displayName	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
eventOf	[Pathway:R-SSC-196757] Metabolism of folate and pterines - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Homo sapiens
input	[SimpleEntity:R-ALL-5693984] 5,10-methylene-THF [mitochondrial matrix] [SimpleEntity:R-ALL-159549] Gly [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
output	[SimpleEntity:R-ALL-379732] L-Ser [mitochondrial matrix] [SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-6797913] SARDH:FAD oxidatively demethylates SARC to Gly - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5694137
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-196757] Metabolism of folate and pterines
(inferredTo)	[Reaction:R-HSA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser

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