Reactome | activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10518759] protein serine/threonine kinase activity of activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Sus scrofa [Reaction:R-SSC-5672978] RAF phosphorylates MAP2K dimer - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10518729
displayName	activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
hasComponent	[Complex:R-SSC-5672685] MAP2K2 dimer [cytosol] [DefinedSet:R-SSC-169291] MAPKs [cytosol] [Complex:R-SSC-5672718] p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] [CandidateSet:R-SSC-5672717] RAF/MAPK scaffolds [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] - Homo sapiens
maxDepth	11
name	activated RAF:scaffold:MAP2K:MAPK complex
producedByEvent	[Reaction:R-SSC-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-5672720
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-SSC-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-SSC-5672978] RAF phosphorylates MAP2K dimer
(physicalEntity)	[CatalystActivity:10518759] protein serine/threonine kinase activity of activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
(output)	[Reaction:R-SSC-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
(hasComponent)	[Complex:R-SSC-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane]
(inferredTo)	[Complex:R-HSA-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]