Reactome | RAF/MAPK scaffolds [cytosol]

Schema > CandidateSet > Entries

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10518723
displayName	RAF/MAPK scaffolds [cytosol]
hasCandidate	[EntityWithAccessionedSequence:R-SSC-5672589] KSR2 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-5626371] IQGAP1 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-5672629] CNKSR1 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-5672632] CNKSR2 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-264470] ARRB1 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-416464] ARRB2 [cytosol] - Sus scrofa [Complex:R-SSC-354079] Focal Adhesion/Focal contacts [plasma membrane] - Sus scrofa
hasMember	[Complex:R-SSC-5672691] p-S311 KSR1:MARK3 [cytosol] - Sus scrofa
inDisease	false
inferredFrom	[CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol] - Homo sapiens
maxDepth	10
name	RAF/MAPK scaffolds
producedByEvent	[Reaction:R-SSC-5672980] Dissociation of RAS:RAF complex - Sus scrofa
schemaClass	CandidateSet
species	[Species:49633] Sus scrofa
stId	R-SSC-5672717

(output)	[Reaction:R-SSC-5672980] Dissociation of RAS:RAF complex
(input)	[Reaction:R-SSC-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
(hasComponent)	[Complex:R-SSC-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] [Complex:R-SSC-5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] [Complex:R-SSC-5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
(inferredTo)	[CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol]