Reactome | IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane]

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - Sus scrofa [Complex:R-SSC-452095] IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-452108] Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment - Sus scrofa [Reaction:R-SSC-452091] Phosphorylation of IL2RB Y338 enables SHC recruitment - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10481053
displayName	IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-SSC-447099] IL2 [extracellular region] [EntityWithAccessionedSequence:R-SSC-450046] IL2RA [plasma membrane] [Complex:R-SSC-451911] IL2RG:JAK3 [plasma membrane] [EntityWithAccessionedSequence:R-SSC-452093] phospho-IL2RB [plasma membrane] [EntityWithAccessionedSequence:R-SSC-451921] phospho-p-Y-JAK1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-452119] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] - Homo sapiens [Complex:R-HSA-452104] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] - Homo sapiens
maxDepth	3
name	IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3
producedByEvent	[Reaction:R-SSC-919404] Phosphorylated STAT5 is released - Sus scrofa [Reaction:R-SSC-452122] JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-452119
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-SSC-919404] Phosphorylated STAT5 is released [Reaction:R-SSC-452122] JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
(input)	[Reaction:R-SSC-452108] Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment [Reaction:R-SSC-452091] Phosphorylation of IL2RB Y338 enables SHC recruitment
(hasComponent)	[Complex:R-SSC-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] [Complex:R-SSC-507943] IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] [Complex:R-SSC-452095] IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] [Complex:R-SSC-453099] IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane]
(inferredTo)	[Complex:R-HSA-452119] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] [Complex:R-HSA-452104] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane]

IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] Show undefined attributes

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