Reactome | TAK1 complex [cytosol]

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TAK1 complex [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10482531] MAP kinase kinase kinase activity of TAK1 complex [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-5357837] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] - Sus scrofa [Complex:R-SSC-2685689] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] - Sus scrofa [Complex:R-SSC-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] - Sus scrofa [Complex:R-SSC-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex - Sus scrofa [Reaction:R-SSC-5607759] TRIKA2 binds K63polyUb-TRAF6 oligomer - Sus scrofa [Reaction:R-SSC-446870] Polyubiquitinated TRAF6 binds the TAK1 complex - Sus scrofa [Reaction:R-SSC-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Sus scrofa [Reaction:R-SSC-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Sus scrofa [Reaction:R-SSC-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Sus scrofa [Reaction:R-SSC-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Sus scrofa [Reaction:R-SSC-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Sus scrofa [Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Sus scrofa [Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Sus scrofa [Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Sus scrofa [Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Sus scrofa [Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Sus scrofa [Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10479808
displayName	TAK1 complex [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-SSC-168156] MAP3K7 [cytosol] [EntityWithAccessionedSequence:R-SSC-167923] TAB1 [cytosol] [DefinedSet:R-SSC-446874] TAB2,TAB3 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-450277] TAB1:TAB2,TAB3:TAK1 [cytosol] - Homo sapiens [Complex:R-HSA-446878] TAK1 complex [cytosol] - Homo sapiens
maxDepth	3
name	TAK1 complex
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-446878
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-SSC-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex [Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation [Reaction:R-SSC-5607759] TRIKA2 binds K63polyUb-TRAF6 oligomer [Reaction:R-SSC-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 [Reaction:R-SSC-446870] Polyubiquitinated TRAF6 binds the TAK1 complex [Reaction:R-SSC-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex [Reaction:R-SSC-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) [Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex
(hasComponent)	[Complex:R-SSC-5357837] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] [Complex:R-SSC-5607672] p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] [Complex:R-SSC-2685689] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] [Complex:R-SSC-450185] hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol] [Complex:R-SSC-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] [Complex:R-SSC-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] [Complex:R-SSC-450186] hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] [Complex:R-SSC-706477] PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol]
(physicalEntity)	[CatalystActivity:10482531] MAP kinase kinase kinase activity of TAK1 complex [cytosol]
(inferredTo)	[Complex:R-HSA-450277] TAB1:TAB2,TAB3:TAK1 [cytosol] [Complex:R-HSA-446878] TAK1 complex [cytosol]

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