Reactome | DEGS1 dehydrogenates dihydroceramide

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DEGS1 dehydrogenates dihydroceramide Show undefined attributes

catalystActivity	[CatalystActivity:10477744] sphingolipid delta-4 desaturase activity of DEGS1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10477746
displayName	DEGS1 dehydrogenates dihydroceramide
eventOf	[Pathway:R-SSC-1660661] Sphingolipid de novo biosynthesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8959462] SAMD8 transfers phosphatidyl from PE onto C16DH CER - Sus scrofa [Reaction:R-SSC-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) - Sus scrofa
inferredFrom	[Reaction:R-HSA-428259] DEGS1 dehydrogenates dihydroceramide - Homo sapiens
input	2 × [Complex:R-SSC-9842697] CYB5B:Fe2+ [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-428126] DHCE [endoplasmic reticulum membrane] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DEGS1 dehydrogenates dihydroceramide dihydroceramide + 2Fe(2+) + 2H+ + O2 => (4E)-ceramide + 2Fe(3+) + 2H2O
output	[SimpleEntity:R-ALL-9842380] (4E)-CERA [endoplasmic reticulum membrane] 2 × [Complex:R-SSC-9842694] CYB5B:Fe3+ [endoplasmic reticulum membrane] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-SSC-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-428259
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-SSC-8959462] SAMD8 transfers phosphatidyl from PE onto C16DH CER [Reaction:R-SSC-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum)
(inferredTo)	[Reaction:R-HSA-428259] DEGS1 dehydrogenates dihydroceramide

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