Reactome | Small interfering RNA (siRNA) biogenesis

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Small interfering RNA (siRNA) biogenesis Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557327
displayName	Small interfering RNA (siRNA) biogenesis
eventOf	[Pathway:R-SSC-211000] Gene Silencing by RNA - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23309] siRNA processing
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-426464] Dicer cleaves double-stranded RNA to yield double-stranded siRNA - Sus scrofa [BlackBoxEvent:R-SSC-2106625] Duplex siRNA is loaded into Argonaute - Sus scrofa [BlackBoxEvent:R-SSC-2106615] Removal of siRNA passenger strand - Sus scrofa [Reaction:R-SSC-9023912] AGO2 cleaves passenger strand of duplex siRNA - Sus scrofa [Reaction:R-SSC-9023909] C3PO hydrolyzes cleaved passenger strand - Sus scrofa
inferredFrom	[Pathway:R-HSA-426486] Small interfering RNA (siRNA) biogenesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Small interfering RNA (siRNA) biogenesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-426486
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-211000] Gene Silencing by RNA
(inferredTo)	[Pathway:R-HSA-426486] Small interfering RNA (siRNA) biogenesis

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