Reactome | SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine

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SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine Show undefined attributes

catalystActivity	[CatalystActivity:10470677] amino acid transmembrane transporter activity of SLC1A4 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10470683
displayName	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
eventOf	[Pathway:R-SSC-352230] Amino acid transport across the plasma membrane - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-375417] SLC36A1-mediated uptake of glycine, proline, and alanine - Sus scrofa [Reaction:R-SSC-352174] SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine - Sus scrofa [Reaction:R-SSC-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - Sus scrofa [Reaction:R-SSC-352119] SLC38A1 (ATA1)-mediated uptake of neutral amino acids - Sus scrofa [Reaction:R-SSC-352108] SLC38A2 (ATA2)-mediated uptake of neutral amino acids - Sus scrofa [Reaction:R-SSC-375487] SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol - Sus scrofa
inferredFrom	[Reaction:R-HSA-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Homo sapiens
input	[DefinedSet:R-ALL-352355] alanine, serine, threonine, or cysteine [cytosol] [SimpleEntity:R-ALL-352036] L-Ala [extracellular region] [SimpleEntity:R-ALL-83910] Na+ [cytosol] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
output	[DefinedSet:R-ALL-352359] alanine, serine, threonine, or cysteine [extracellular region] [SimpleEntity:R-ALL-29432] L-Ala [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-352364
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-352230] Amino acid transport across the plasma membrane
(precedingEvent)	[Reaction:R-SSC-375417] SLC36A1-mediated uptake of glycine, proline, and alanine [Reaction:R-SSC-352174] SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine [Reaction:R-SSC-352182] SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [Reaction:R-SSC-352119] SLC38A1 (ATA1)-mediated uptake of neutral amino acids [Reaction:R-SSC-352108] SLC38A2 (ATA2)-mediated uptake of neutral amino acids [Reaction:R-SSC-375487] SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
(inferredTo)	[Reaction:R-HSA-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine