Reactome | STK11 (LKB1) phosphorylates NUAK1

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STK11 (LKB1) phosphorylates NUAK1 Show undefined attributes

catalystActivity	[CatalystActivity:10506734] protein serine/threonine kinase activity of TP53 Tetramer:STK11:NUAK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10506736
displayName	STK11 (LKB1) phosphorylates NUAK1
eventOf	[Pathway:R-SSC-6804756] Regulation of TP53 Activity through Phosphorylation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-3222020] NUAK1 phosphorylates TP53 - Sus scrofa
inferredFrom	[Reaction:R-HSA-3222006] STK11 (LKB1) phosphorylates NUAK1 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-SSC-6805036] TP53 Tetramer:STK11:NUAK1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	STK11 (LKB1) phosphorylates NUAK1
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-SSC-6805037] TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm]
precedingEvent	[Reaction:R-SSC-6805035] TP53 binds STK11 and NUAK1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-3222006
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6804756] Regulation of TP53 Activity through Phosphorylation
(precedingEvent)	[Reaction:R-SSC-3222020] NUAK1 phosphorylates TP53
(inferredTo)	[Reaction:R-HSA-3222006] STK11 (LKB1) phosphorylates NUAK1

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