Reactome | 5S-HpETE is dehydrated to LTA4 by ALOX5

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5S-HpETE is dehydrated to LTA4 by ALOX5 Show undefined attributes

catalystActivity	[CatalystActivity:10470003] oxidoreductase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10470181
displayName	5S-HpETE is dehydrated to LTA4 by ALOX5
eventOf	[Pathway:R-SSC-2142700] Biosynthesis of Lipoxins (LX) - Sus scrofa [Pathway:R-SSC-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-2162019] LTA4 is converted to EXA4 by ALOX15 - Sus scrofa [Reaction:R-SSC-266072] LTA4 is hydolysed to LTB4 by LTA4H - Sus scrofa [Reaction:R-SSC-266050] LTA4 is converted to LTC4 by LTC4S - Sus scrofa
inferredFrom	[Reaction:R-HSA-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 - Homo sapiens
input	[SimpleEntity:R-ALL-266010] 5S-HpETE [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	5S-HpETE is dehydrated to LTA4 by ALOX5 (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4 Dehydration of 5-HpETE to leukotriene A4
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-265281] LTA4 [cytosol]
precedingEvent	[Reaction:R-SSC-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-266051
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2142700] Biosynthesis of Lipoxins (LX) [Pathway:R-SSC-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(precedingEvent)	[Reaction:R-SSC-2162019] LTA4 is converted to EXA4 by ALOX15 [Reaction:R-SSC-266072] LTA4 is hydolysed to LTB4 by LTA4H [Reaction:R-SSC-266050] LTA4 is converted to LTC4 by LTC4S
(inferredTo)	[Reaction:R-HSA-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5

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