Reactome | LTA4 is converted to EXA4 by ALOX15

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LTA4 is converted to EXA4 by ALOX15 Show undefined attributes

catalystActivity	[CatalystActivity:10501888] leukotriene-C4 synthase activity of ALOX15:Fe2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10501890
displayName	LTA4 is converted to EXA4 by ALOX15
eventOf	[Pathway:R-SSC-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-2161768] EXA4 is converted to EXC4 by LTC4S - Sus scrofa
inferredFrom	[Reaction:R-HSA-2162019] LTA4 is converted to EXA4 by ALOX15 - Homo sapiens
input	[SimpleEntity:R-ALL-265281] LTA4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LTA4 is converted to EXA4 by ALOX15
output	[SimpleEntity:R-ALL-2142772] EXA4 [cytosol]
precedingEvent	[Reaction:R-SSC-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2162019
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(precedingEvent)	[Reaction:R-SSC-2161768] EXA4 is converted to EXC4 by LTC4S
(inferredTo)	[Reaction:R-HSA-2162019] LTA4 is converted to EXA4 by ALOX15

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