Reactome | ROCK1 [cytosol]

candidateOf	[CandidateSet:R-SSC-9018917] RHOH effectors [cytosol] - Sus scrofa
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-9680444] ROCK1,ROCK2:ROCKi [cytosol] - Sus scrofa [Complex:R-SSC-422483] Activated ROCK:RhoA/B/C:GTP [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-3928576] RHOA:GTP binds ROCK, activating it - Sus scrofa [Reaction:R-SSC-9680443] ROCK1,2 bind ROCKi - Sus scrofa [Reaction:R-SSC-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Sus scrofa [Reaction:R-SSC-201611] Caspase-mediated cleavage of Rock-1 - Sus scrofa [Reaction:R-SSC-419049] ROCK activation by RHO - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10466355
displayName	ROCK1 [cytosol]
endCoordinate	1354
inDisease	false
inferredFrom	[DefinedSet:R-HSA-419057] ROCK1,ROCK2 [cytosol] - Homo sapiens [DefinedSet:R-HSA-4687776] Activated ROCK1,ROCK2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-4687777] Activated ROCK1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-212509] ROCK1 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[CandidateSet:R-SSC-9020314] RHOBTB1 interacting proteins [cytosol] - Sus scrofa [CandidateSet:R-SSC-9696288] RND3 effectors [cytosol] - Sus scrofa [CandidateSet:R-SSC-9013052] RHOB effectors (plasma membrane) [cytosol] - Sus scrofa [CandidateSet:R-SSC-9013138] RHOC effectors [cytosol] - Sus scrofa [CandidateSet:R-SSC-9013003] RHOA plasma membrane effectors [cytosol] - Sus scrofa
name	ROCK1 A0A5G2QIS7
referenceEntity	[ReferenceGeneProduct:uniprot:A0A5G2QIS7] UniProt:A0A5G2QIS7
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49633] Sus scrofa
stId	R-SSC-212509
startCoordinate	2

(hasMember)	[CandidateSet:R-SSC-9013003] RHOA plasma membrane effectors [cytosol] [CandidateSet:R-SSC-9696288] RND3 effectors [cytosol] [CandidateSet:R-SSC-9013138] RHOC effectors [cytosol] [CandidateSet:R-SSC-9020314] RHOBTB1 interacting proteins [cytosol] [CandidateSet:R-SSC-9013052] RHOB effectors (plasma membrane) [cytosol]
(hasCandidate)	[CandidateSet:R-SSC-9018917] RHOH effectors [cytosol]
(input)	[Reaction:R-SSC-3928576] RHOA:GTP binds ROCK, activating it [Reaction:R-SSC-419049] ROCK activation by RHO [Reaction:R-SSC-9680443] ROCK1,2 bind ROCKi [Reaction:R-SSC-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 [Reaction:R-SSC-201611] Caspase-mediated cleavage of Rock-1
(hasComponent)	[Complex:R-SSC-422483] Activated ROCK:RhoA/B/C:GTP [plasma membrane] [Complex:R-SSC-9680444] ROCK1,ROCK2:ROCKi [cytosol] [Complex:R-SSC-3928564] RHOA:GTP:ROCK1,ROCK2 [plasma membrane] [Complex:R-SSC-5228987] RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]
(inferredTo)	[DefinedSet:R-HSA-419057] ROCK1,ROCK2 [cytosol] [DefinedSet:R-HSA-4687776] Activated ROCK1,ROCK2 [cytosol] [EntityWithAccessionedSequence:R-HSA-4687777] Activated ROCK1 [cytosol] [EntityWithAccessionedSequence:R-HSA-212509] ROCK1 [cytosol]

ROCK1 [cytosol] Show undefined attributes

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